Birbla

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Hacker News

I am sure in some countries this vaccine will be made mandatory for all teenagers because the assumption is they will have unprotected sex, even if you're a loner.

by alightsoul

I have to admit that given how many times we have been here, I struggle with being excited about any news about a HIV vaccine until we see results from humans. Just way too many times of hope.

That being said, I don't understand enough to parse this very buzzword heavy release. Is this fundamentally different than the every 6 month vaccine we have now and is a more traditional vaccine or is it just continuing on that trend?

by nerdjon

Can anyone explain why the body doesn’t just naturally make lots of These broadly neutralising antibodies?

It seems like they’d be so useful - so there must be a good reason there aren’t lots of them normally?

by jonplackett

Tested on rhesus macaques. Worked well for 44% of them.

It's a positive step, but still a fair way off for humans.

by AndrewDucker

Phase I trials happening now. Godspeed to them. It’s where most HIV vaccines die

by khalic

While HIV vaccine research is an exciting field, it's worth pointing out that halting HIV transmission is, practically speaking, a solved problem with oral and injectable reverse transcriptase inhibitors. The ongoing loss of life and health due to HIV could be stopped if we cared enough to invest resources in wide-scale PrEP availability and public health education. Waiting for an HIV vaccine is the domain equivalent of hoping fusion power will solve our energy needs. Other solutions exist already; we just have to use them.

by RGS1811

The most interesting point of the article for me is that this vaccine appears to be a series of shots which act as a curriculum for the immune system. Each one slightly different and targeting a different stage of B-cell development. I've never thought of vaccine series working like that, so it was a new and impressive idea.

by iandanforth

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  • Hacker News
  • I am sure in some countries this vaccine will be made mandatory for all teenagers because the assumption is they will have unprotected sex, even if you're a loner.
    by alightsoul
  • I have to admit that given how many times we have been here, I struggle with being excited about any news about a HIV vaccine until we see results from humans. Just way too many times of hope.

    That being said, I don't understand enough to parse this very buzzword heavy release. Is this fundamentally different than the every 6 month vaccine we have now and is a more traditional vaccine or is it just continuing on that trend?

    by nerdjon
  • Can anyone explain why the body doesn’t just naturally make lots of These broadly neutralising antibodies?

    It seems like they’d be so useful - so there must be a good reason there aren’t lots of them normally?

    by jonplackett
  • Tested on rhesus macaques. Worked well for 44% of them.

    It's a positive step, but still a fair way off for humans.

    by AndrewDucker
  • Phase I trials happening now. Godspeed to them. It’s where most HIV vaccines die
    by khalic
  • The actual paper - never trust press releases from authors' institutions: https://www.nature.com/articles/s41586-026-10837-5

    Peer review files: https://media.springernature.com/original/springer-static/es...

    Independent article covering it: https://cen.acs.org/pharmaceuticals/vaccines/hiv-vaccine-can...

    by croemer
  • While HIV vaccine research is an exciting field, it's worth pointing out that halting HIV transmission is, practically speaking, a solved problem with oral and injectable reverse transcriptase inhibitors. The ongoing loss of life and health due to HIV could be stopped if we cared enough to invest resources in wide-scale PrEP availability and public health education. Waiting for an HIV vaccine is the domain equivalent of hoping fusion power will solve our energy needs. Other solutions exist already; we just have to use them.
    by RGS1811
  • The most interesting point of the article for me is that this vaccine appears to be a series of shots which act as a curriculum for the immune system. Each one slightly different and targeting a different stage of B-cell development. I've never thought of vaccine series working like that, so it was a new and impressive idea.
    by iandanforth