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  • Hacker News
  • "Others are exploring their use for treating sleep apnoea, which is a far more common disorder." CPAP biomedical equipment manufacturer watch out!
    by madhacker
  • Sleep less and sit more. What a species we’ve become.
    by almost_usual
  • With so much malformed/fake diagnosis out there for mental health the data, research and conclusions will be a mess obscuring and obfuscating truth.

    The only way through will be anecdata. Science of one.

    I await basic safety reports.

    by brador
  • Well, they're filming the next season of black mirror right now, it's probably not too late to throw this one in there.
    by fedpost
  • Its going to be 12 episodes of "What if Datacenter took my water" and similar isnt it?
    by protocolture
  • I like sleep - it's not a problem to be solved.
    by wewewedxfgdf
  • Since we’re talking narcolepsy here, your passengers might disagree
    by WesolyKubeczek
  • 185 comments 2 weeks ago: https://news.ycombinator.com/item?id=49263658
    by WalterGR
  • Interesting comment: https://news.ycombinator.com/item?id=49264602

    > IMO the much more likely explanation is that the brain uses contrastive learning somewhere. [...] Instead of using calculus and outer products to calculate derivatives, you feed real data and false data forward through the network and each neuron tracks and trains on the difference.

    by Kinrany
  • Despite the stigma surrounding semaglutide, its impact across various health conditions has been remarkable. Bringing that same level of innovation to cognitive disorders could be truly transformative for society
    by fishfasell
  • I've not detected a stigma around semaglutide.

    Is it from these Valley Bros I read about experimenting with designer semaglutide on themselves? Or is there another stigma?

    by JKCalhoun
  • If this means I don't have to take Methylphenidate to function 100% all the time and as a result feel tremendously anxious 100% all the time. SIGN ME UP.
    by fennec-posix
  • You sure about that math?
    by SV_BubbleTime
  • FWIW, I was on MP for years and never really liked it. Tried all possible dosages and delivery methods. I switched to lisdexamfetamine a couple of years ago and never looked back. 0 side effects apart from my mouth.
    by mial
  • Adding guanfacine (Intuniv) to my methylphenidate took the weird anxious-angry edge off. Would be nice to not have to take one med to fix the side effects of the other, though.
    by didgeoridoo
  • The second I read the print in Nature a bit ago I knew some version would show up here. I swear I’ve met deployed Marines less obsessed with staying awake through chemistry than some people here.
    by EA-3167
  • Do they sell caffeinated crayons yet? If not I have a startup idea-
    by AnneTrotter
  • 1. Virtue signaling.

    2. Unhealthy desire to get rich (or work on interesting projects, which would be the better option).

    by oblio
  • It sounds like is a genuine treatment for those who suffer from narcolepsy, and everything else is merely speculative and has seem pretty bad side-effects.
    by SoupBread
  • There is evidence that some forms of ADHD are effectively just the brain falling asleep rapidly and then waking up. This form cam be attenuated with norepinephrine reuptake inhibitor alone. Presents with ADHD like symptoms. But it’s a new thing most likely. Called “Cognitive Disengagement Syndrome”.
    by bitexploder
  • https://archive.md/LWDUq
    by Anon84
  • My partner has had idiopathic hypersomnia (sleeps 12 hours most days, as much as 18 hours some days) for a few years now, and so far nothing we’ve tried has worked without awful side effects (e.g. constant heart palpitations and panic attacks.)

    I had been looking into orexin agonists (along with other things like H3 autoreceptor antagonists) back when they were just a concept. It’s good to see them finally reaching commercialization. Although they’re not approved by our own (Canadian) regulatory body quite yet.

    Now that they’re approved in the US, though, I’m looking very much forward to seeing how these drugs perform in off-label-ish treatment of the various other sleep disorders that I’m sure clinicians will now begin throwing them at.

    by derefr
  • Have they tried GHB? I know it's used in narcolepsy patients with great success. If you "microdose" it, it's also one of the best drugs on the planet. Slippery slope, though.
    by chasebank