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- Hacker News
- As someone with experience in this field (and plenty of skepticism of geographic association studies), I find the article lacking. Is there a technical write-up?
It is quite odd that the authors say that they don’t know if the original method can yield negative results. Some of the results are expressed as relative risk, so there’s a numerator and denominator. That should be enough to begin to work it out, since all possible exclusive numerators sum to the denominator. It feels like if you don’t understand whether some areas will be lower than average, then perhaps you don’t understand the method sufficiently.
It sounds like they reverse engineered the original method, but that means they could be applying an overfit model and getting spurious results that the original wouldn’t give.
That’s all speculation, hence we need the technical write up.
by chrisvls - > Over the last several months, we have replicated the results of these papers. The authors supplied us with eight lines of code and answered a couple of questions about the covariates, which did not replicate the results. Most of our replication was done through first principles combined with trial and error. Once we were reasonably close to the results of the first national study on cancer mortality, we took the methodology and applied it to numerous other landmarks.
Any details of the methodology? Is it possible some mistakes were made during this "trial and error"?
edit: Some aggregated data is available from https://pmc.ncbi.nlm.nih.gov/articles/PMC12929679/ , but far from enough to reproduce: https://media.springernature.com/original/springer-static/es...
by verteu - Some methodology issues with the first paper are described on PubPeer:
https://pubpeer.com/publications/AEA87585FB0365719098E2C0D06...
by dbcooper - I hoped to see a systematic explanation of what the correlations show. As long as we don't have a viable explanation, there is something interesting there to discover. It can be that the statistical analysis is fundamentally flawed. Pointing out a flaw that tricked several serious researchers is progress. If it was because of some other factor (let's assume there are many more elderly people living around those neighborhoods, can't think of a better example now).by aljgz
- Cancer risk associations studies are not normally described as "proving" anything. The article being criticized uses 'risk' and 'association'. There is a long history of argument around these sorts of studies, there was a previous series of these around people living near power plants (where it seems like SES, not plant proximity, was the strongest explanatory variable, see https://www.aps.org/archives/publications/apsnews/200710/ele... ). I've seen similar "living near a freeway causes cancer" arguments. There was a massive court case by flight attendants, who have a higher rate of cancer than the regular population.
In reading the criticism, I noticed the authors keep using the term "prove" and they also keep trying to come up with mechanisms ("refueling of the plant"). Even the argument about plant worker exposure compared to people living far away doesn't completely work, because the plant workers are taking all sorts of precautions to minimize exposure to radiation, but there are still mechanisms where something could go out the cooling stacks and deliver something harmful downwind.
The biophysics of cancer causation is entirely nontrivial and looking for the actual sources of the cancer risk is challenging, and watching physics people argue with epidemiologists gets old quickly (my field is biophysics, and I've had a few physics people insist that non-ionizing radiation couldn't possibly cause cancer, "because it doesn't damage DNA". Unfortunately, that argument isn't good, because it presupposes a mechanism (DNA damage due to radiation); we know now that non-ionizing radiation causes cellular heating, stress response, and more, which are all associated (based mostly on in vitro studies) with increased rate of cancer.
Note the authors (and the institute they work for) have vested interest: Dr. Adam Stein is the Director of the Nuclear Energy Innovation program at the Breakthrough Institute, where his work centers on the technology, regulation, economics, and risk governance of advanced nuclear energy.
Deric Tilson is a Senior Nuclear Energy Innovation Analyst at The Breakthrough Institute, where he focuses on advancing nuclear energy as a critical pathway to a carbon-free and energy-abundant future.
by dekhn - "Over the last several months, we have replicated the results of these papers. The authors supplied us with eight lines of code and answered a couple of questions about the covariates, which did not replicate the results. Most of our replication was done through first principles combined with trial and error. Once we were reasonably close to the results of the first national study on cancer mortality, we took the methodology and applied it to numerous other landmarks."
Author implies that Alwadi et al. was not forthcoming with sharing the data underlying their studies. Because otherwise they should be able to exactly replicate their results. "Reasonably close" does not cut it.
by bjourne - Did I miss it, or do the authors not bother to explain how the original methodology is wrong? Do we just take their word for it?by hatthew
- Every time I come across an article about cancer, I'm reminded of that website that catalogued all the things that The Daily Mail said either caused or prevented cancer.
https://web.archive.org/web/20200221175201/http://kill-or-cu...
Too bad it's down, but here's an archive of it.
by Magi604