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  • Hacker News
  • > randomized, placebo-controlled clinical evidence

    :)

    > data from a...clinical trial of 108 adults with HIV associated lipohypertrophy

    :(

    by howunfortunate
  • It says 42% of treatment group showed slower aging, and reduction in telomere length... is there an effect size published anywhere?
    by plutomeetsyou
  • Let's play spot the conflict of interest. Three of seven authors tied to a company selling biological aging tests. One consults for Merck, GSK, etc.

    There seems some promise at times but I also struggle to see the recent slew of "GLP-1s cure X", where X is seemingly any ailment known to man, as much more than the next Big Pharma gold rush where the profits dwarf any eventual regulatory fines, and taxpayers and real patients are left with the costs.

    by Murfalo
  • > slows down the accumulation of biological aging markers in the DNA of adults with HIV

    And if you don’t have HIV?

    by andsoitis
  • >They also reduce visceral and ectopic fat that accumulates around the abdomen and organs, which may help curb the inflammatory and metabolic signals that promote aging.

    Interesting, I wonder if someone will do a study where they pair a GLP-1 with tesamorelin to see if there's any synergy there in terms of fat reduction and reduced aging.

    by GenerWork
  • Isn't being "underweight" generally shown to reduce the speed of aging
    by froobius
  • I'm excited to see more studies done in this context, but without the HIV association. My wife has Ehlers-Danlos Syndrome and Rheumatoid Arthritis. She saw more benefits in inflammation reduction than weight reduction, especially those first two weeks she started taking it. She says her pain levels are night and day difference when on GLP-1 vs off. To me it would then make logical sense that reduced inflammation can have a measurably positive effect on aging.
    by y-c-o-m-b
  • I'm always confused with these type of posts because I feel the scientists must know something I don't. Why is it always does GLP-1 help with [general health thing]?

    If I understand it correctly, GLP-1 drugs help people with weight loss. People are more healthy when they're not overweight, and GLP-1s help people get down to a healthier weight. So when we ask questions about do GLP-1s help this or that, isn't there a giant confounding variable here? That being overweight causes a litany of health issues has been common knowledge forever now. Thus, my (uninformed, intuitive) guess would just be that GLP-1s, which cause weight loss, also include the subsequent effects of healthy weight loss.

    So why are we surprised then that people going from overweight to a healthy weight slows aging, or betters cardiovascular health as I've seen elsewhere? Aren't these already well-studied effects of healthy weight loss? Shouldn't these positive effects obviously just be attributed to weight loss, rather than the thing that causes the weight loss? And why are there articles about this stuff acting like this is unexpected?

    I admit I'm a laymen and I hope don't sound too snide or critical here. I'm just kind of puzzled by this out of genuine curiosity.

    by manlymuppet

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