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  • Hacker News
  • Before or after 2020?
    by HPsquared
  • Side note every male in their 40s should go get on crestor to control their cholesterol. I didn’t because I was afraid of side effects. I finally started it and had no side effects. Wasted a decade. Control your blood pressure. Anxiety is a totally different thing when it pushes you into hypertensive crises ie stroke territory.

    Edit specifically American men or anywhere where the common diet is similarly terrible

    by le-mark
  • Access to the study requires $17,500 per year, just fyi.
    by esalman
  • If all the other biomarkers of inflammation "showed no correlation with the presence of coronary inflammation" as predicted by this scan, then how exactly do they assess the positive predictive value of the scan?
    by jp57
  • > Crucially, no routine blood biomarker, lipid metric, or clinical risk score could identify these individuals with inflamed coronary arteries.

    I call bs on this. There are two common blood tests that are meant for it:

    1) hs-CRP (High-sensitivity CRP)

    2) Lp-PLA2: Lipoprotein-associated phospholipase A2 (Lp-PLA2), also known as platelet activating factor Acetylhydrolase, is an inflammatory enzyme that circulates bound mainly to low density lipoproteins and has been found to be localized and enriched in atherosclerotic plaques. In multiple clinical trials, Lp-PLA2 activity has been shown to be an independent predictor of coronary heart disease and stroke in the general population. Measurement of Lp-PLA2 may be used along with traditional cardiovascular risk factor measures for identifying individuals at higher risk of cardiovascular disease events.

    I have routinely had both of these blood tests among others, although I paid myself to get them.

    As for hs-CRP, it will likely show an elevation. If you use a binary classifier with a higher threshold of what's safe, e.g. 3.0 instead of 1.0, you will miss it! I am guessing this is why they missed it.

    by throw20261022
  • This particular study looked at inflammation through imaging (CT scans) as part of Biograph's $17,500 program. You can get at the underlying signal fairly cheaply through a simple blood test (hs-CRP).

    It's fairly well-known that inflammation is an independent risk factor for heart disease, alongside LDL cholesterol (or ApoB) and blood pressure: https://www.empirical.health/blog/inflammation-and-heart-hea...

    The American College of Cardiology looked at a bunch of inflammation biomarkers and standardized on hs-CRP: https://www.jacc.org/doi/10.1016/j.jacc.2025.08.047

    by brandonb
  • AI analysis of this press release finds high a likelihood that it was written by... AI.

    Their homepage has (bottom left corner) FOUR DIFFERENT AI AGENTS waiting to explain to you why you should pay for the SUBSCRIPTION HEALTH SERVICE.

    I'm sorry, I'm no doctor, but this strikes me as health FOMO marketing. It's a press release, not a scientific paper.

    by Rantenki
  • I don't see how one can spin this into a positive finding - their preprint says that the only correlate they find with their new measurement is BMI. By my reading, not even male sex is associated with more inflammation. It sounds like they've identified a fancy BMI estimator, and not a very good one.

    This is in asymptomatic patients, who already have a great estimator for 10-year heart disease mortality risk in the coronary calcium score which isn't even obliquely mentioned in their abstract. Edit: the paper shows no correlation with calcium, either

    https://www.medrxiv.org/content/10.64898/2026.10.19.26364786...

    by bonsai_spool

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